
But there's been
a SIGNIFICANT reduction
in the tumors.
Breaking Bad Season 2, Episode 10

I brought SIGNIFICANT assets
into the relationship too.
The Big Bang Theory Season 8, Episode 6

Well, you've lived with
your SIGNIFICANT other for some time.
The Big Bang Theory Season 10, Episode 4

Gentlemen, please!
This is a SIGNIFICANT decision.
The Big Bang Theory Season 10, Episode 7

...I'm going to go do work
that promises SIGNIFICANT results...
The Big Bang Theory Season 2, Episode 2